Amyloidosis
From the Autoimmune Association List Only
Summary
Amyloidosis is a disorder in which abnormal proteins build up in tissues and organs. The cause of primary amyloidosis is unknown. The condition is related to abnormal and excess production of antibodies by a type of immune cell called plasma cells. Clumps of abnormal proteins build up in certain organs. This reduces their ability to work correctly. Symptoms depend on the organs affected. This disease can affect the tongue, intestines, skeletal and smooth muscles, nerves, skin, ligaments, heart, liver, spleen, and kidneys. Symptoms include: abnormal heart rhythm, fatigue, numbness of hands or feet, shortness of breath, hoarseness or changing voice, and joint pain.
(Autoimmune Association, 2022)
Symptoms
You may not experience symptoms of amyloidosis until later in the course of the disease. Symptoms may vary, depending on which organs are affected.
Signs and symptoms of amyloidosis may include:
Severe fatigue and weakness
Shortness of breath
Numbness, tingling, or pain in the hands or feet
Swelling of the ankles and legs
Diarrhea, possibly with blood, or constipation
An enlarged tongue, which sometimes looks rippled around its edge
Skin changes, such as thickening or easy bruising, and purplish patches around the eyes
(Autoimmune Association, 2022)
Diagnostic Criteria
Under Investigation
Diagnostic Tests
Under Investigation
Human Leukocyte Antigen (HLA) Associations
Under Investigation
Tissue-Type or Cell-Type Attacked
Under Investigation
Attacking Immune Cell Type or Process
Under Investigation
Treatment Modality
Under Investigation
Managing Specialist(s)
Under Investigation
Associated Infections
Under Investigation
Associated Toxins
Under Investigation
Research Authors
Under Investigation
Research Institutions
Under Investigation
Average Time from Symptom Onset to Diagnosis
Under Investigation
Last Updated
January 02, 2023
References
Amyloidosis. Autoimmune Association. (2022, November 09). Retrieved January 02, 2023 from https://autoimmune.org/disease-information/amyloidosis/