*Lymphocytic colitis / Microscopic colitis

From the Global Autoimmune Institute List Only

Summary

Microscopic colitis is a chronic inflammatory disease of the colon that is characterized by chronic, watery, non-bloody diarrhea. It typically occurs in middle-aged patients and has a female preponderance. The colon appears typically normal or almost normal on colonoscopy in patients with microscopic colitis. The diagnosis is established by biopsy of the colonic mucosa demonstrating characteristic histologic changes. Microscopic colitis, first described in 1980 [1], has two main histologic subtypes, lymphocytic colitis, more specifically defined in 1989 [2], and collagenous colitis.

(UptoDate, 2022)

Symptoms

Under Investigation

Diagnostic Criteria

Under Investigation

Study Classification Criteria

Under Investigation

Diagnostic Tests

Under Investigation

Organized Autoimmunity

(Alternative Autoimmune Disease Classification: FIEM, MIEM or BIEM, or FEM, MEM or BEM)

1. sex predominance (is an autoimmune disease primarily found in genetic Females, Males, or equally in Both?)

   1. Under Investigation

2. Inherited and acquired gene variations that cause increased susceptibility

   1. Human Leukocyte Antigen (HLA) Associations

      1. Under Investigation

   2. Other Gene Variations (mutations)

      1. Under Investigation

3. Gene Triggering Environmental Exposures

   1. Infections

      1. COVID-19 (Chang et. al, 2023, found a significantly higher risk of inflammatory bowel disease following COVID-19 infection in a study of 3,814,479 participants)

   2. Toxins

      1. Under Investigation

   3. Stress

      1. Needs to be assessed for each patient

4. Multiple interactive and destructive immune system pathologies

   1. Under Investigation

Tissue-Type or Cell-Type Attacked

Under Investigation

Treatment(s)

Under Investigation

Managing Specialist(s)

Under Investigation

Research Authors

Under Investigation

Research Institutions

Under Investigation

Average Time from Symptom Onset to Diagnosis

Under Investigation

Last Updated

September 05, 2023

References

Chang R, Yen-Ting Chen T, Wang SI, Hung YM, Chen HY, Wei CJ. Risk of autoimmune diseases in patients with COVID-19: A retrospective cohort study. EClinicalMedicine. 2023 Feb;56:101783. doi: 10.1016/j.eclinm.2022.101783. Epub 2023 Jan 10. PMID: 36643619; PMCID: PMC9830133.

Microscopic (lymphocytic and collagenous) colitis: Clinical manifestations, diagnosis, and management. UptoDate. (2022, July 20). Retrieved September 05, 2023 from https://www.uptodate.com/contents/microscopic-lymphocytic-and-collagenous-colitis-clinical-manifestations-diagnosis-and-management