Human Leukocyte Antigen Variation Links Multiple sclerosis and Localized scleroderma (Morphea)
autoimmunedx.substack.com
What do Multiple sclerosis and Localized scleroderma share? There’s the obvious association in their names: they’re both a type of sclerosis (or hardening), but the similarities seem to stop there. One is a brain disease and one is a skin disease. Yet, they share a striking thing: the association with Human Leukocyte Antigen (HLA) variation HLA DRB1*15:01. This is a Class II variation, which means that it appears on antigens (molecules that antibodies can react to) on Antigen Presenting Cells only, like B cells, a type of white blood cell called a lymphocyte.
Human Leukocyte Antigen Variation Links Multiple sclerosis and Localized scleroderma (Morphea)
Human Leukocyte Antigen Variation Links…
Human Leukocyte Antigen Variation Links Multiple sclerosis and Localized scleroderma (Morphea)
What do Multiple sclerosis and Localized scleroderma share? There’s the obvious association in their names: they’re both a type of sclerosis (or hardening), but the similarities seem to stop there. One is a brain disease and one is a skin disease. Yet, they share a striking thing: the association with Human Leukocyte Antigen (HLA) variation HLA DRB1*15:01. This is a Class II variation, which means that it appears on antigens (molecules that antibodies can react to) on Antigen Presenting Cells only, like B cells, a type of white blood cell called a lymphocyte.