(Ngo et. al, 2014) Sex predominance is one of the similarities that link Systemic sclerosis and Localized scleroderma. Systemic sclerosis is reported to have a female to male ratio of 3:1 or possibly higher (Peoples et. al, 2016). Localized scleroderma is reported to have a female to male ratio of 4:1 (Papara et. al, 2021). I wanted to delve deeper into why that might be. There’s the Leptin Theory of sex predominance in autoimmune disorders—quickly summarized as the divergence between males and females, at adolescence, of hormones secreted from fat tissues. You can read my post about The Leptin Theory
Sex Predominance & the X Escapee
Sex Predominance & the X Escapee
Sex Predominance & the X Escapee
(Ngo et. al, 2014) Sex predominance is one of the similarities that link Systemic sclerosis and Localized scleroderma. Systemic sclerosis is reported to have a female to male ratio of 3:1 or possibly higher (Peoples et. al, 2016). Localized scleroderma is reported to have a female to male ratio of 4:1 (Papara et. al, 2021). I wanted to delve deeper into why that might be. There’s the Leptin Theory of sex predominance in autoimmune disorders—quickly summarized as the divergence between males and females, at adolescence, of hormones secreted from fat tissues. You can read my post about The Leptin Theory